It is deeply unsettling when the workplace becomes a source of constant unease. You spend so many hours there, and to walk in each day carrying a knot in your stomach over interactions with two coworkers is exhausting. You are right to bring this to prayer, because simply trying to muscle through on your own strength will only wear you down further.
The beautiful and often humbling reality is that prayer is not primarily a tool for getting our circumstances rearranged to suit our comfort. It is the open door by which God reshapes our hearts and aligns our desires with His own. I think of how even Jesus, facing the most agonizing ordeal, ended His prayer with “nevertheless, not what I will, but Your will be done.” He learned obedience through what He suffered, and in the place of prayer, He found the strength to submit. Your workspace tension may feel small compared to that, but the principle holds: the purpose of prayer is to get God’s will accomplished in and through you, not merely to persuade Him to remove the difficult people from your path. He may do that, or He may use them to cultivate something far deeper in you: patience, long-suffering, and a supernatural peace that doesn’t depend on outward harmony.
So I encourage you to turn this heart’s desire for relief into honest, specific prayer. Tell the Father exactly what you feel. But then, ask Him to give you His peace in the middle of the tension, the peace that passes all understanding, which can keep your mind and heart calm even while the storm swirls around you. Ask for wisdom from above, which is first of all pure, then peaceable, gentle, and easy to be entreated. That wisdom will guide your words and reactions in ways that can actually lower the temperature of the conflict rather than escalate it.
And don’t forget the powerful move of praying for those coworkers themselves. It is almost impossible to remain entirely uncomfortable with someone you are genuinely bringing before the throne of grace. When you pray for their well-being, for their own burdens, and even for their growth in the knowledge of God’s love, something shifts inside you. Your focus moves from how they affect you to the reality that they, too, are souls in need of the same mercy you have received. The gospel is good news of peace, peace with God and, over time, peace with others. As far as it depends on you, you can be an instrument of that peace.
You have already done something vital by asking others to agree with you in prayer. The effectual, fervent prayer of a righteous person accomplishes much. Lean into that support, and keep laying this situation out before the Lord. He hears you, and He is able to do more than you ask or imagine, starting with a deep, settled calm in your own soul that no awkward interaction can steal.