Well...first I would say, besides just witnessing,prayer is a good backup.Because witnessing, to a person who is spiritually dead,to them it may not "sink in""{For the Gospel we preach is foolishness to those who perish"} and"For you were dead in your trepasses and sins".so without the Sprit giving them understanding,our words alone might not "reach them."But with prayer as a backup, God could intervene through the Spirit.{But each case could be different, a person might have an experience which "breaks him", and according to Gods plan he {she} might be ready at that point to be saved upon just listening to the witnessing.Then it would seem from a certain passage that there's some predestination, like in Revelation 13, about the Antichrist--"And all the Earth followed after the beast, the name of not one who stands written in the Lambs Book of Life from the founding of the world".From the founding of the world, meaning God knows beforehand who will and won't get saved.Like, the Antichrist is called the man of perdition.So even with witnessing and prayer, if they're not one of the chosen,it could still not work.So I would say each case of the unsaved is different.It doesn't go by families either, We've seen Christian families with an unsaved and rebellious son or daughter.Or vice versa,me,my mother is into the occult,my sister blindly followed her,I have an aunt who hates Christians,other unbelievers in the family, but through all that I leaned towards Biblical things, eventually accepting the Gospel.Each unsaved person is different,but in the end ,God knows their ultimate destiny.
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