We hear your deep concern and frustration over what you see as a rebellion against God’s created order, and we share your grief over the ways the world has twisted His design. The Scripture you referenced is profound and sobering: "Because, knowing God, they didn’t glorify him as God, neither gave thanks, but became vain in their reasoning, and their senseless heart was darkened. Professing themselves to be wise, they became fools... Therefore God also gave them up in the lusts of their hearts to uncleanness, that their bodies should be dishonored among themselves" (Romans 1:21-22, 24 WEB). This passage indeed warns that when people reject God, He may allow their minds to be darkened, leading them into confusion and distortion of His truth.
Your observation about the spiritual implications of living unsaved is biblically sound. When someone is separated from God, their understanding of His design, including gender, marriage, and the roles He established, becomes warped. The enemy seeks to distort everything God called "good" (Genesis 1:31). This is why we see such widespread confusion today: women rejecting motherhood, men rejecting their calling to lead and protect, and entire cultures celebrating what God calls sin. The apostle Paul warns, "For the time will come when they will not listen to the sound doctrine, but, having itching ears, will heap up for themselves teachers after their own lusts" (2 Timothy 4:3 WEB). This is the fruit of a world that has turned away from God.
To your specific question, can living unsaved warp your reasoning to the point of denying God’s created design?, the answer is a resounding yes. The Bible makes it clear that the unsaved mind is hostile to God (Romans 8:7) and cannot understand spiritual things (1 Corinthians 2:14). Without the Holy Spirit, people are easily deceived by the lies of the world, the flesh, and the devil. This is why we see such confusion about gender, sexuality, and even basic biology. The enemy has sown deception, and those who reject God are left vulnerable to it.
But we must also address the heart behind your observations. While it is right to grieve over sin and rebellion, we must guard our own hearts against bitterness or pride. The women you describe are not the enemy, they are captives to the enemy’s lies, just as all of us were before Christ saved us. Our role is not to condemn but to pray for them and, when given the opportunity, to speak the truth in love (Ephesians 4:15). Jesus came to seek and save the lost (Luke 19:10), and we are called to do the same.
We must also be careful not to oversimplify the struggles of others. While it is true that unsaved people are blinded by sin, not every person who struggles with gender confusion or other issues is unsaved. Some may be believers who are wounded, deceived, or battling deep spiritual oppression. Our response should always be compassion, coupled with a firm commitment to biblical truth. We are called to love the sinner while hating the sin, just as Christ did.
Now, let us pray together for the women you’ve observed, for those struggling with confusion, and for the church to rise up with clarity and compassion:
Heavenly Father, we come before You with heavy hearts, grieving over the ways the world has twisted Your beautiful design. Lord, we know that when people reject You, their minds become darkened, and they are led into confusion and sin. We pray for the women who are rejecting their God-given roles, who are deceived by the lies of the enemy, and who are pursuing paths that lead to destruction. Open their eyes, Father. Break the chains of deception and draw them to Yourself. Let them see the beauty of Your design for their lives, for motherhood, for marriage, for their bodies as temples of the Holy Spirit.
We also pray for the men who are struggling, who feel lost in this confusion. Strengthen them to stand firm in Your truth, to lead with courage and love, and to be a light in this dark world. Father, we ask that You would raise up godly men and women who will boldly proclaim Your Word and live out Your design for marriage, family, and gender. Protect the church from the lies of the enemy, and give us wisdom to speak the truth in love.
Lord, we know that only in You can true clarity be found. Only in Jesus can the blind see and the captive be set free. We pray that all who are lost would come to know Him as their Savior and Lord. May Your Spirit move powerfully in this generation, turning hearts back to You and restoring what has been broken.
We ask all these things in the mighty name of Jesus, the Name above all names, the only Name by which we can be saved. Amen.
To you, dear brother, we encourage you to keep your heart soft and your eyes fixed on Jesus. It is easy to grow discouraged or even angry when we see the world’s rebellion, but remember that our battle is not against flesh and blood (Ephesians 6:12). The enemy is the one who sows deception, and our weapon is the truth of God’s Word. Continue to pray, to love, and to speak truth with gentleness and respect. The harvest is plentiful, but the laborers are few (Matthew 9:37). Will you be one who labors for the Lord?
Prayer Focus: God, Thank You for loving me. Thank You for loving me, Jesus. God, I ask You in Jesus’ name please bless me with everything that I stand in need of and everything You want me to have. 
