We understand that you're feeling isolated, lonely, and concerned about the continuation of your family bloodline. First, let's pray for you and your family, and then we will address your concerns from a biblical perspective.
Dear Heavenly Father,
We come before You in the name of Jesus Christ, lifting up our sister who is feeling lonely, isolated, and worried about the future of her family bloodline. We know that You see her and care for her deeply. We pray that You would comfort her heart, and remind her that You are always with her, even to the end of the age, as You promised in Matthew 28:20 WEB, "Behold, I am with you always, even to the end of the age."
Lord, we also pray for her as she grieves the loss of her parents and uncle. We ask that You would be her God, her comforter, and her friend in this time of need. We pray that You would provide for her and help her to live a fulfilled life, even if it looks different than she had originally planned. We ask that You would guide her as she navigates her relationships and future decisions. Lord, we pray that You would show her that her life has great value and purpose, and that it will not be forgotten.
Lastly, Lord, we pray for her family bloodline. We ask that if it is Your will, You would provide a way for her family name to be carried on, whether through adoption or another means. We trust in Your goodness and Your plan for her life and the lives of her family members. We ask all of these things in the precious name of Jesus Christ WEB, "Whatever you will ask in my name, that will I do, that the Father may be glorified in the Son. If you will ask anything in my name, I will do it." John 14:13-14
Now, let's address your concerns from a biblical perspective. First, it's important to remember that God's family is eternal. When we put our faith in Jesus Christ, we become part of His family, and that is a family that will never end. As it says in Romans 8:15-17 WEB, "For you didn't receive the spirit of bondage again to fear, but you received the Spirit of adoption, by whom we cry, 'Abba! Father!' The Spirit himself testifies with our spirit that we are children of God; and if children, then heirs; heirs of God, and joint heirs with Christ."
Second, it's wonderful that you have a heart for adoption. This is a beautiful picture of what God has done for us, as He adopted us into His family. If God leads you to adopt, we encourage you to follow His guidance and trust that He will provide for you and your child.
Third, we want to gently remind you that having children and continuing a family bloodline is not the only way to have a fulfilled life. God has a unique purpose and plan for each of us, and that plan might look different than we expect. We encourage you to seek God's will for your life and trust that He has good plans for you, as He promises in Jeremiah 29:11 WEB, "For I know the thoughts that I think toward you," says Yahweh, "thoughts of peace, and not of evil, to give you hope and a future."
Fourth, we want to address the fact that you did not mention the name of Jesus Christ, Jesus, or Christ in your prayer request. It is only by the name of Jesus that we receive what we ask of the Father. As scripture proclaims in John 14:6, Jesus saith unto him, I am the way, the truth, and the life: no man cometh unto the Father, but by me. If you are not saved, it is very important to give your life to Christ.
Finally, we want to encourage you to continue reaching out to your relatives, even if they live far away. You can still be a blessing to them and build meaningful relationships with them, even if you don't see them often. And remember, your family is not just defined by blood relations. As you mentioned, you do have friends. Continue to invest in those friendships and allow God to bring more people into your life to love and support you.
Prayer Focus: God, Thank You for loving me. God, I ask You in Jesus’ name please bless me with everything that I stand in need of and everything You want me to have. 
